Francis Crick Institute

The Medical Research Council (MRC) Biomedical NMR Centre is a multi-user national facility for biomolecular NMR. The Centre is part of The Francis Crick Institute in London, and supports studies on fundamental biology of health and disease. The main focus is solution-state studies, with biological-solid state NMR capabilities to be added in the second half of 2020.

The facility is open to UK-based academic users.  Applications for long-term access are considered annually and are subject to peer-review by an external committee.  Occasional access can also be arranged by direct application to the facility.  Projects are expected to fall broadly within the MRC and Crick remits.

Contacts:
Dr. Tom Frenkiel 

NMR Equipment

Ultra-High Field (>800 MHz)

Bruker Avance III HD 950 MHz narrow bore NMR spectrometer equipped with 5 mm 1H/13C/15N He-cooled cryoprobe with cooled preamplifiers for all three channels, the 1H channel is tuneable to 19F, with single axis pulsed-field gradients and deuterium decoupling; the console is equipped with dual receivers.

Very-High Field (700-800 MHz)

Bruker Avance III HD 800 MHz narrow bore NMR spectrometer equipped with a 5 mm 1H/13C/15N triple-resonance He-cooled cryoprobe with cooled preamplifiers for all three channels, with single axis pulsed-field gradients and deuterium decoupling; the 1H channel is tuneable to 19F.

Bruker Avance III HD 700 MHz narrow bore NMR spectrometer equipped with a 5 mm 1H/31P/13C/15N quadruple-resonance He-cooled cryoprobe with cooled 1H, 13C and 31P preamplifiers, with single axis pulsed-field gradients and deuterium decoupling; the 1H channel is tuneable to 19F. The console is equipped with dual receivers.

Bruker Avance III HD 700 MHz narrow bore NMR spectrometer equipped with a 5 mm 1H/13C/15N triple-resonance He-cooled cryoprobe with cooled preamplifiers for all three channels, with single axis pulsed-field gradients and deuterium decoupling; the 1H channel is tuneable to 19F.

New solid state capability will include two triple-resonance CP-MAS probes, one for 3.2 mm rotors and the other for ultrafast (up to 67 KHz) MAS with 1.3 mm rotors which will be used as alternates of the cryoprobe.

All the three very-high field instruments are equipped with cooled Bruker SampleJet sample changers for 5 mm (550 μl) and 3 mm (180 μl) NMR tubes, with a capacity of five NMR tube racks (each holding up to 96 samples, so 480 sample tubes in total.

Additional capabilities

Bruker Avance III 600 MHz narrow bore NMR spectrometer equipped with a 4 mm HR-MAS probe for studies of biological tissues.