Francis Crick Institute
The Medical Research Council (MRC) Biomedical NMR Centre is a multi-user national facility for biomolecular nuclear magnetic resonance (NMR). The Centre is part of The Francis Crick Institute in London, and supports studies on fundamental biology of health and disease. Facilities are available for solution-state, biological solid-state, and HR-MAS studies, with solution-state being the main focus.
The facility is open to UK-based academic users. Applications for long-term access are considered annually and are subject to peer-review by an external committee. Occasional access can also be arranged by direct application to the facility. Projects are expected to fall broadly within the MRC and Crick remits.
Contacts:
Dr. Tom Frenkiel
NMR Equipment
Ultra-High Field (>800 MHz)
Bruker Avance III HD 950 MHz NMR spectrometer equipped with 5 mm 1H/13C/15N Cryoprobe with cooled preamplifiers for all three channels, the 1H channel is tuneable to 19F, with single axis pulsed-field gradients and deuterium decoupling; the console is equipped with dual receivers.
Very-High Field (700-800 MHz)
Bruker Avance III HD 800 MHz NMR spectrometer equipped with a 5 mm 1H/13C/15N triple-resonance Cryoprobe with cooled preamplifiers for all three channels, with single axis pulsed-field gradients and deuterium decoupling; the 1H channel is tuneable to 19F.
Bruker Avance III HD 700 MHz NMR spectrometer equipped with a 5 mm 1H/31P/13C/15N quadruple-resonance Cryoprobe with cooled 1H, 13C and 31P preamplifiers, with single axis pulsed-field gradients and deuterium decoupling; the 1H channel is tuneable to 19F. The console is equipped with dual receivers.
Bruker Avance III HD 700 MHz narrow bore NMR spectrometer equipped for both solution-state and solid-state studies. Solution-state work is supported by a 5 mm 1H/13C/15N triple-resonance He-cooled cryoprobe with cooled preamplifiers for all three channels, single axis pulsed-field gradients and deuterium decoupling; the 1H channel is tuneable to 19F. For solid-state work, two 1H/13C/15N CP-MAS probes are available, one for 1.3mm rotors spinning at up to 67 kHz, and the other for 3.2mm rotors at spinning speeds up to 24kHz.
All the three Very-High Field instruments are equipped with cooled Bruker SampleJet sample changers for 5 mm (550 ml) and 3 mm (180 ml) NMR tubes, with a capacity of five NMR tube racks (each rack holding up to 96 samples, so 480 sample tubes in total).
Additional capabilities
Bruker Avance III 600 MHz narrow bore NMR spectrometer which can be equipped with a 4 mm HR-MAS probe for studies of biological tissues.