University of Leicester

The Leicester Institute of Structural and Chemical Biology was created in 2016 to bring together established strengths in structural biology, chemical biology and single-molecule research from across the Colleges. The Institute takes advantage of synergies in research technologies and approaches to deliver major advances in both fundamental and translational research.

Contacts:
Prof. John Schwabe (Institute Director), Prof. Geerten Vuister (NMR spectroscopy)

NMR Equipment

Very-High Field (700-800 MHz)

Bruker Avance NEO 800 MHz narrow bore NMR spectrometer equipped with He-cooled cryoprobes and a cooled automated SampleCASE™ sample changer (24 position) for tubes with spinners.

Solution state probes:

  • 5 mm 13C-optimised triple resonance (1H, 13C/15N, 2H TXO) cryoprobe, z-gradient, T: -40°C to +80°C, automated tuning and matching
  • 5 mm 1H-optimised triple resonance (1H, 13C, 15N, 2H TXI) probe, z-gradient, T: -40°C to +80°C, automated tuning and matching
  • 5 mm Insight Cell Flow unit for monitoring chemical reactions, or metabolites in biological processes.

Solid state probes:

  • 3.2 mm EFREE (13C/15N/1H) MAS probe for RF heating reduction, maximum MAS frequency 24 kHz, T: -30°C to +70°C
  • 4 mm HR-MAS probe (1H/13C/15N), z-gradient, maximum MAS frequency 15 kHz, T: -20°C to +80°C

High Field (600 MHz)

Bruker Avance III HD 600 MHz wide bore equipped with a 4 mm EFREE (13C/15N/1H) MAS probe for RF heating reduction, maximum MAS frequency 16 kHz, T: -30°C to +70°C