Bruker Avance Neo 800 MHz narrow bore four channel NMR spectrometer equipped with a temperature-controlled SampleJet automatic sample changer, with capacity for up to 480 samples. The magnet is equipped with a 5 mm TCI (1H, 13C, 15N, 2H) cryoprobe, z-gradient, with automated tuning and matching and variable temperature capability. It is a proton-optimised triple resonance probe with three fully independent channels (plus lock channel), optimised for 1H and 13C observation. The cryogenically cooled preamplifier for the deuterium channel results in excellent stability and allows use of low concentration deuterated solvents. It also performs well with shaped NMR tubes for use with lossy samples.