University of Bath
The Dynamic Reaction Monitoring (DReaM) Facility is part of the wider NMR service provided within the Chemical Characterisation Facility at the University of Bath. The DReaM Facility uses flowNMR coupled with other analytical techniques (gas and solution phase mass spectrometry, HPLC, UV/Vis, polarimetry) to analyse reaction mixtures directly from the reaction vessel, which can be housed either in the fume cupboard or glove box.
Since 2017, we have been hosting an annual Reaction Monitoring Symposium to foster networking and collaboration in the fields of NMR and Reaction Monitoring.
All access to the DReaM Facility is charged. There are two access routes – a high priority industrial access route and a route for standard priority work whereby a call for proposals is held. Calls for proposals are held twice yearly, typically in January and July. You can find out more information about applying for time here.
Contacts:
Dr. Catherine Lyall
NMR Equipment
Additional capabilities
Bruker Avance III HD 500 MHz NMR spectrometer equipped with N2-cooled Prodigy cryoprobe (which can observe 15N-31P, as well as 1H and 19F) and InsightMR flowtubes and software. Reaction temperatures of -20 to +80 °C are achievable (probe T: -40°C to +80°C) and reaction pressures up to 10 bar can generally be accommodated.
Although no reaction is “typical”, we generally use protonated solvents and use flow rates of up to 4 mL/min.
Bruker Avance Neo 500 MHz NMR spectrometer equipped with an iProbe TBO 5mm BBF/31P/1H and a Bruker Avance Neo 400 MHz spectrometer equipped with an iProbe TBO 5mm BBF/19F/1H.
Bruker Avance Neo 500 MHz NMR spectrometer equipped with an iProbe BBO H&F where the inner NMR coil can be tuned to observe any nucleus in the range from 31P-199Hg and 17O-103Rh. We’ve been able to run 1H-103Rh experiments with success (direct detection 103Rh has worked well with the high concentration test samples we’ve used, but real samples at low concentration may still require unreasonable timeframes).