Dr Ryan Mewis of Manchester Metropolitan University has edited the special edition ‘Signal Amplification by Reversible Exchange (SABRE)’ of Magnetic Resonance in Chemistry by Wiley. SABRE was first reported by the group of Duckett (2009). It is a hyperpolarisation technique used in NMR and MRI which dramatically enhances magnetic resonance signals. The articles published in this special issue provide information about SABRE and other hyperpolarisation techniques. Articles also illustrate the developments in the SABRE method and how challenges related to this technique are being overcome.