Recent work of researchers from the University of Edinburgh together with their collaborators, published in European Journal of Organic Chemistry, have shown how stopped flow NMR technique can be used to capture short-liver information embedded in rapid irreversible chemical reactions.
In-situ NMR spectroscopic analysis of homogeneous reactions is an essential tool for mechanistic analysis in organic and organometallic chemistry. However, rapid non-equilibrium reactions that are initiated by mixing require specialized approaches. In this study researchers have performed stopped flow NMR spectroscopy using insert that is compatible with a standard NMR spectrometer fitted with a He or N2 cryoprobe, to study the kinetics of rapid irreversible reactions such as the protodeboronation of 2,3,4,5,6-pentafluorophenyl boronate (2 b, t1/2=0.12 s at 300 K). Resrachers have also analysed effects of spin relaxation, pre-magnetization, heat-transfer versus reaction enthalpy, and mixing-efficiency.
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